Registration Dossier
Registration Dossier
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EC number: 279-505-5 | CAS number: 80584-91-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
no further studies available
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Short description of key information:
In the present studies an examination of the reproductive organs was
included. Especially in the 90 day study with Sprague-Dawley rats with
repeated oral dosing up to 1000 mg/kg bw (Martin et al. 2002) clinical
examination and even histopathology revealed no changes of the
reproductive organs. In these studies the maximum applicable dosages
were administered without causing any toxic effect.
Justification for selection of Effect on fertility via oral route:
In the present studies an examination of the reproductive organs was
included. Especially in the 28 day and 90 day studies with
Sprague-Dawley rats with repeated oral dosing up to 1000 mg/kg bw
(Martin et al. 2001 and Martin et al. 2002) clinical examination and
even histopathology revealed no changes of the reproductive organs. In
these studies the maximum applicable dosages were administered without
causing any toxic effect.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available studies (Martin et al. 2001 and Martin et al. 2002) and evaluation in IUCLID section 7.1.1, 7.8.1 and 7.8.2 the substance is not classified according to the criteria of Regulation (EC) No.: 1272/2008 and Directive 67/548/EEC.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
