Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-784-1 | CAS number: 99-75-2
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset Substance ID: 99-75-2
- Author:
- IUCLID
- Year:
- 2 000
- Bibliographic source:
- http://esis.jrc.ec.europa.eu/ with reference to Montefibre S.p.A
- Report date:
- 2000
- Reference Type:
- secondary source
- Title:
- Fragrance raw materials monographs. Methyl p-toluate
- Author:
- Opdyke DLJ
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology, Vol. 17 Suppl. 183-184
- Report date:
- 1979
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- 48-h closed patch test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl p-toluate
- EC Number:
- 202-784-1
- EC Name:
- Methyl p-toluate
- Cas Number:
- 99-75-2
- Molecular formula:
- C9H10O2
- IUPAC Name:
- methyl 4-methylbenzoate
- Test material form:
- not specified
- Details on test material:
- 8 % of test substance in petrolatum
Constituent 1
Method
- Subjects:
- no data
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- No irritation was observed after 48 h of occlusive exposure
Applicant's summary and conclusion
- Conclusions:
- In this 48-h closed patch test the test substance (8 % in petrolatum) was not irritating to human skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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