Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
55 mg/kg bw/day
Study duration:
subchronic
Species:
rat
Quality of whole database:
The NOAEL of the base form of MBB was calculated from the sulfate form NOAEL (90 mg/kgbw/d).

Additional information

Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
Although the test was performed on the sulfate form, the toxicological data generated at pH > 4.5 are directly applicable to MBB (see speciation document in section 1.4)

Justification for classification or non-classification

The substance is not classified for repeated toxicity effects.