Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

No effects up to the limit of the water solubility of the substance.
LC50 (96 h) > 10,000 mg a.i./L (nominal) for Danio rerio (ISO 7346-1)

Key value for chemical safety assessment

Additional information

One study investigating the short-term toxicity of D-Glucose, reaction products with alcohols C16-18 (even numbered) (excess) to fish is available. In this key study performed according to ISO 7346 -1 and GLP, Danio rerio was exposed to nominal concentrations of 100, 300, 1000, 3000 and 10,000 mg/L of a product containing 30% APG and 70% fatty alcohol in a semi-static test design. Analytical verification of the test substance concentrations was attempted by TOC measurement, but could not be performed successfully as undissolved substance gathered at the water surface. No mortality was observed in any treatment nor in the control, therefore an LC0 (96 h) value of 10,000 mg/L (nominal) and an LC50 (96 h) value of > 10,000 mg/L was reported. Hence it can be concluded that there is no short-term toxicity to fish up to the limit of the water solubility of the substance (Henkel, 1993).

Two other supporting studies investigated the short-term toxicity of C16 fatty alcohol and C18 fatty alcohol, respectively, to Oncorhynchus mykiss according to GLP and OECD guideline 203 (SafePharm, 1996 and 1996). These data from category member substances are considered suitable for read-across based on a category approach. The substances were applied at 0.4 mg/L nominal in a limit test and semi-static design, and a solvent was used to achieve this concentration which is above the water solubility limit of the substances. No effects were observed in the tests, and an LC50 (96 h) value of > 0.4 mg/L was stated. Accordingly it can be confirmed that there is no short-term toxicity to fish up to the limit of the water solubility of the substances.

This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 and justified in detail in the overall summary (IUCLID Chapter 6.1) and within the category justification attached in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Nevertheless, as it can be seen in the data matrix of the category justification in IUCLID Section 13 and the overall summary (IUCLID Chapter 6.1), all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.