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Short-term toxicity to fish

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Description of key information

Parent compound butyryl chloride: With high probability acutely not harmful to aquatic organisms.
Hydrolysis product butyric acid: No valid data available, therefore the risk assessment based on read-across to the structurally similar substance isobutyric acid.
Isobutyric acid: With high probability acutely not harmful to aquatic organisms.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
146.6 mg/L

Additional information

Parent compound butyryl chloride and hydrolysis product butyric acid:

The acute fish toxicity of butyryl chloride (141 -75 -3) was determined with Danio rerio according to OECD 203 ( Fish, Acute Toxicity Test). Butyryl chloride hydrolyses rapidly, therefore the fish were mainly exposed to its hydrolysis products butyric acid and hydrochloric acid. The obtained LC50 (96 h) was 299 mg/L. When tested under neutralised conditions (pH-adjustment), the LC50 was > 464 mg/L (BASF, 1998; 10F0451/965162). Based on the available data, the substance is assessed to be with high probability acutely not harmful to fish. The assessment is enhanced by read across to butyric acid (CAS 107 -92 -6) and isobutyric acid (CAS 79 -31 -2). Results for butyric acid as cited in Onitsuka et al. 1989 and Juhnke 1978 are not suitable for todays regulatory purposes as the exposure period is only 48 h instead of 96 h.

Isobutyric acid:

The toxicity of isobutyric acid was tested to the test organism Leuciscus idus according to Germany Industrial Standard Guideline DIN 38412, part L 15. The 96 -h LC50 was determined to be 146.6 mg/L (BASF AG 1989, 10F0167/895107).

Hydrolysis product hydrochloric acid (HCl):

HCl was tested in a semi-static acute toxicity test according to OECD 203 with Cyprinus carpio. The 96-h LC50 was 4.92 mg/L (acid equivalent to pH 4.3; OECD, 2002).

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