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EC number: 201-178-4 | CAS number: 79-11-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source only
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Chloroacetic acid, CAS No: 79-11-8
- Author:
- OECD SIDS
- Year:
- 1 996
- Bibliographic source:
- http://www.inc hem.org/doc uments/sids/s ids/79118.pdf
- Reference Type:
- publication
- Title:
- Differential toxicity of monochlaracetate, monofluorate and moniodoacetate in rats
- Author:
- Hayes, F.D. et al.,
- Year:
- 1 973
- Bibliographic source:
- Toxicology and Applied Pharmacology, 26, 93-102
Materials and methods
- Principles of method if other than guideline:
- Rats received subcutaeous injections of the test substance to evaluate acute toxicity.
- GLP compliance:
- no
Test material
- Reference substance name:
- Chloroacetic acid
- EC Number:
- 201-178-4
- EC Name:
- Chloroacetic acid
- Cas Number:
- 79-11-8
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- chloroacetic acid
- Details on test material:
- - Name of test material (as cited in study report): Chloracetic acid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 108 mg/kg bw
- Based on:
- test mat.
- Mortality:
- A LD50 of 108 mg chloracetic acid/kg bw was determined in rats after subcutaneous exposure in the conducted study.
Applicant's summary and conclusion
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