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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source only

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Chloroacetic acid, CAS No: 79-11-8
Author:
OECD SIDS
Year:
1996
Bibliographic source:
http://www.inc hem.org/doc uments/sids/s ids/79118.pdf
Reference Type:
publication
Title:
Differential toxicity of monochlaracetate, monofluorate and moniodoacetate in rats
Author:
Hayes, F.D. et al.,
Year:
1973
Bibliographic source:
Toxicology and Applied Pharmacology, 26, 93-102

Materials and methods

Principles of method if other than guideline:
Rats received subcutaeous injections of the test substance to evaluate acute toxicity.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroacetic acid
EC Number:
201-178-4
EC Name:
Chloroacetic acid
Cas Number:
79-11-8
Molecular formula:
C2H3ClO2
IUPAC Name:
chloroacetic acid
Details on test material:
- Name of test material (as cited in study report): Chloracetic acid
- Analytical purity: no data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
108 mg/kg bw
Based on:
test mat.
Mortality:
A LD50 of 108 mg chloracetic acid/kg bw was determined in rats after subcutaneous exposure in the conducted study.

Applicant's summary and conclusion