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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: ECHA inquiry result
Title:
Unnamed
Year:
1999

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 84/449/EWG, B.3
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(hydroxyphenylphosphinyl)propanoic acid
EC Number:
411-200-6
EC Name:
3-(hydroxyphenylphosphinyl)propanoic acid
Cas Number:
14657-64-8
Molecular formula:
C9H11O4P
IUPAC Name:
3-[hydroxy(phenyl)phosphoryl]propanoic acid

Test animals

Species:
other: rat, Sprague Dawley

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: Mit Wasser angefeuchtet "ENGLISH" Moistered with water
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Alle Tiere überlebten die Studie. Es wurden keine klinischen Symptome festgestellt. Im Vergleich mit der Kontrollgruppe konnten keine Effekte beobachtet werden. "ENGLISH" Mortality: There were no deaths. CLINICAL
Gross pathology:
Effects on organs:
Es wurden keine Effekte beobachtet.
"ENGLISH"
No findings were observed.
Other findings:
Signs of toxicity (local):
Es wurden keine lokalen Effekte beobachtet.
"ENGLISH"
No local signs of toxicitiy were observed during
the study period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU