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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Aug 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Analytical monitoring:
yes
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
48 h
Duration:
48 h
Dose descriptor:
EC0
Effect conc.:
>= 0.031 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
dissolved
Basis for effect:
mortality
Validity criteria fulfilled:
yes
Conclusions:
The test susbtance is not toxic to Daphnia magna up to the solubility level.
Executive summary:

20 Daphnia were exposed to BAY 43 -9006 in a saturated solution (nominal concentration: 0.5 mg/L) and a control in a limit test over a period of 48h. Immobilization was recorded at 24 and 48 h. No immobilized Daphnia were observed during the test. Thus the EC0 was higher than a saturated solution, measured with </= 0.031 mg/L.

Description of key information

A guideline study according to OECD Guideline 202 (Daphnia sp. Acute Immobilization Test) was performed under GLP to assess the acute toxicity of BAY 43-9006 to Daphnia magna. A group of 20 Daphnia were exposed to BAY 43 -9006 in a saturated solution (nominal concentration: 0.5 mg/L) and a control in a limit test over a period of 48h. Test concentrations were analysed by HPLC/UV. Due to the low solubility of the test substance, the test concentration of the saturated solution was determined to be approximately between 0.031 and 0.047 mg/L. Observations on immobilization of Daphnia were recorded at 24 and 48 h after start of exposure. No immobilized Daphnia were observed during the test. Thus the EC0 was higher than the maximum solubitlity under the test conditions (measured concentration >/= 0.031 mg/L). Hence, the test susbtance is not toxic to Daphnia magna up to the solubility level.


 


 

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
EC50
Effect concentration:
>= 0.031 mg/L

Additional information