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EC number: 608-209-4 | CAS number: 284461-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2008-2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- no
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 475207-59-1
- Cas Number:
- 475207-59-1
- IUPAC Name:
- 475207-59-1
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: particulates
- Details on test material:
- test was performed with the tosylate salt of BAY 43-9006 (sorafenib tosylate=4-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)ureido]phenoxy}pyridine 2-carboxylic acid methylamide 4-methylbenzenesulfonate)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
Results and discussion
Effect concentrations
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.001 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Due to the low water solubility of sorafenibtosylate the test substance was not detectable in most
test solutions.
Only weak effects were observed on the number of off-spring at the three highest concentrations.
No effects were observed on the surviving parent animals and the number of broods.
The NOEC for cumulative offspring was ¿ 0.00086 mg/L. The LOEC was > 0.00086 mg/L
(measured cocentration). - Executive summary:
Ten Daphnia magna were used for each of the 5 test concentrations of sorafenibtosylate and 10
for the dilution water control. The Daphnia were exposed to the test solution and the tap water
for a period of 22 days (start of treatment = day 1) under semi-static conditions, i.e. the solutions
were renewed three times a week. The Daphnia were held individually. The immobilization of
parent animals was recorded every day and the number of living off-spring was recorded at each
change of the test solution 3 times per week starting when the first brood was released.
The NOEC/LOEC of the number of off-spring and the number of broods were statistically
evaluated by the computer program TOXRat Professional XT.
For the preparation of the test solutions a solution with a nominal concentration of 100 mg/L was
ultrasonified for approximately 30 minutes and stirred for approximately 24 hours. This
suspension was filtered through a glass-fiber filter. This solution was used for the highest test
solution and also aliquots of the obtained solution were further diluted 1:3, 1:9, 1:27 and 1:81
with tap water in order to prepare the appropriate test concentrations.
For each change of test solutions the saturated solution and the dilutions were prepared freshly.
Samples of the test solutions were taken weekly for concentration analysis by HPLC
The test temperature was in the range of 19.7 °C to 20.1 °C. The pH was in a range between 7.6
and 8.4 and the oxygen concentration between 7.8 and 8.9 mg/L. The light/dark rhythm was
adjusted to 12 hours/12 hours.
Due to the low water solubility of sorafenibtosylate the test substance was not detectable in most test solutions. Only at the two highest concentrations, detectable levels were found. The NOEC for cumulative offspring was ¿ 0.00086 mg/L. The LOEC was > 0.00086 mg/L(measured cocentration).
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