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EC number: 608-209-4 | CAS number: 284461-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 475207-59-1
- Cas Number:
- 475207-59-1
- IUPAC Name:
- 475207-59-1
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: particulates
- Details on test material:
- test was performed with the tosylate salt of BAY 43-9006 (sorafenib tosylate=4-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)ureido]phenoxy}pyridine 2-carboxylic acid methylamide 4-methylbenzenesulfonate)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 30 min
Results and discussion
Effect concentrations
- Duration:
- 30 min
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Any other information on results incl. tables
The respiration rate in the test vessels was not relevantly inhibited. There was no concentration
related effect. The NOEC was higher than the test range. The test material has a very low solubility, therefore, the activbated sludge was exposed to a saturated solution of the test material.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Sorafenibtosylate had no concentration-depended inhibitory effect on the respiration rate of
activated sludge in the tested range - Executive summary:
The test substance sorafenibtosylate was incubated in aerated activated sludge with
microorganisms from a municipal sewage treatment plant including synthetic sewage feed for
approximately 30 min followed by the measurement of the respiration rate by an oxygen probe.
The synthetic sewage feed solution was made up of mainly peptone, meat extract and urea.
Sorafenibtosylate is only slightly soluble, therefore the test substance was directly introduced
into the test vessel. The amount was 0.5, 1, 2, 4 and 8 mg substance in 42 mL water,
ultrasonified for approximately 30 minutes and constantly stirred for approximately 30 minutes.
Subsequently, the inoculum and synthetic feed was added to each vessel. The resulting nominal
concentrations were 2, 4, 8, 16 and 32 mg/L. Additionally, a reference substance
(3,5-dichlorophenole) in three concentrations (5, 15 and 30 mg/L in test vessel) was prepared.
Since the test material was introduced directly, an analytical verification was not
essential for the interpretation of the results.
As a parameter for the activity of the sludge, the respiration rate was measured with an oxygen
probe. The decrease of the respiration rate was calculated on the basis of the oxygen
consumption per hour.
The respiration rate in the test vessels was not relevantly inhibited. There was no concentration
related effect. The NOEC was equal or higher than the solubility limit of the test substance.
The inhibitory effect of the test and the reference substance at a particular concentration was
expressed as a percentage of the mean respiration rate of the controls
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