Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

There are no guideline toxicokinetic data available (OECD methods 417, 427 or 428) for the test substance. In the absence of experimental data, the toxicokinetic behaviour of the test substance has been evaluated independently (Dhinsa N.K., 2011), based on relevant information available from physico-chemical and toxicological studies; the evaluation was in accordance with applicable EU REACH Technical Guidance (ECHA 2012).  This qualitative assessment concluded that systemic uptake occurs in animals following oral exposure and that dermal absorption is also possible. The evaluation also suggests that once absorbed, distribution and hepatic metabolism will occur, with urine being the main route of excretion.

Key value for chemical safety assessment

Additional information

In accordance with Annex VII (point 8.8) of Regulation (EC) No 1907/2006 (REACH), a paper based toxicokinetics assessment was conducted for the test substance. This was carried out by Harlan Laboratories Ltd (Harlan Reference Number 6512 (Dhinsa N.K., 2011)). Summaries of studies (physico-chemical and toxicological) were reviewed by a qualified toxicologist with a view to fulfilling the requirements of Annex VIII, point 8.8 of REACH. The assessment of likely toxicokinetic behaviour of the test substance was provided to the extent that can be derived from the relevant available information at the time of the assessment. The assessment was based on the Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance (ECHA, May 2008).