Registration Dossier
Registration Dossier
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EC number: 205-736-8 | CAS number: 149-30-4
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A scientific publication.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
- Type of study / information:
- Consumer exposure and occupational exposure
- Endpoint addressed:
- skin sensitisation
- Principles of method if other than guideline:
- No data.
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
Constituent 1
Method
- Details on exposure:
- Common sources of exposure to MBT include rubber gloves, shoes and boots, rubberized fabrics such as brassieres and girdles, rubber money counters, elasticized stockings, and underwear elastic.
Results and discussion
- Results:
- The percentage of positive patch test reactions to MBT and closely related chemicals ranged from 2.1 to 4.4% in dermatitis patients from 1972 to 1981. Higher reaction rates were noted in men. Shoes and gloves are frequent sources of MBT exposure.
Reactions may be elicited by 0.01 % MBT
Applicant's summary and conclusion
- Conclusions:
- The percentage of positive patch test reactions to MBT and closely related chemicals ranged from 2.1 to 4.4% in dermatitis patients from 1972 to 1981. Higher reaction rates were noted in men. Shoes and gloves are frequent sources of MBT exposure.
Reactions may be elicited by 0.01 % MBT - Executive summary:
This review discusses clinical reports and patch testing data demonstrating that mercaptobenzothiazole is sensitizer.
Common sources of exposure to MBT include rubber gloves, shoes and boots, rubberized fabrics such as brassieres and girdles, rubber money counters, elasticized stockings, and underwear elastic.
Consumer exposure to rubber products has resulted in shoe and glove dermatitis, and reactions to scuba diving masks, wet suits, swim caps and goggles, and many cosmetic products.
Occupational exposure to 2-mercaptobenzothiazole may result in hand dermatitis in hospital nurses and other medical personnel.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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