Registration Dossier
Registration Dossier
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EC number: 205-736-8 | CAS number: 149-30-4
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: A scientific study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Principles of method if other than guideline:
- A study during 1-15 days of gestation in rat.
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Reference substance name:
- 2-mercaptobenothiazole
- IUPAC Name:
- 2-mercaptobenothiazole
- Details on test material:
- - Name of test material (as cited in study report):2-mercaptobenothiazole
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- Days 1-15 of gestation
Doses / concentrations
- Remarks:
- Doses / Concentrations:
200 mg/kg
Basis:
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 200 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- 200 mg/kg bw/day
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- NOAEL Maternal: 200 mg/kg bw
NOAEL Teratogen: 200 mg/kg bw - Executive summary:
For 2 -mercaptobenzothiazole were determined: NOAEL Maternal.: 200 mg/kg bw NOAEL Teratogen: 200 mg/kg bw.
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