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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: 2e The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
other: Draize test
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified
Remarks:
Although a GLP statement was not included with the report, it is known that Bushy Run Research Center (BRRC) operated as a GLP facility at the time the testing was conducted.

Test material

Constituent 1
Chemical structure
Reference substance name:
Dichloro(methyl)silane
EC Number:
200-877-1
EC Name:
Dichloro(methyl)silane
Cas Number:
75-54-7
Molecular formula:
CH4Cl2Si
IUPAC Name:
dichloro(methyl)silane
Details on test material:
- Name of test material (as cited in study report): Organochlorosilane A-155
- Substance type: Chlorosilane
- Physical state: Clear yellow liquid
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
No further details available

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
Duration of treatment / exposure:
Four hour(s)
Observation period:
Seven days
Number of animals:
One
Details on study design:
TEST SITE
- Area of exposure: No data
- % coverage: No data
- Type of wrap if used: Occlusive


REMOVAL OF TEST SUBSTANCE
- Washing (if done):yes
- Time after start of exposure: Four hours


SCORING SYSTEM: Draize

Results and discussion

In vivo

Results
Irritation parameter:
other: corrosion
Time point:
other: all time points
Reversibility:
not reversible
Irritant / corrosive response data:
Application of 0.5 ml of the sample to rabbit skin produced severe irritation (necrosis) immediately upon contact.  Necrosis and scabs were apparent at seven days following the dose. 

Any other information on results incl. tables

Immediate necrosis of the skin was observed following the application. Necrosis and scabs were apparent seven days following the exposure. No scores were given.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In a skin irritation study (reliability score 2) comparable to OECD 404, 0.5 ml undiluted dichloro(methyl)silane was corrosive to the skin of one rabbit.
Executive summary:

In a skin irritation study (reliability score 2) comparable to OECD 404, 0.5 ml undiluted dichloro(methyl)silane was applied to the skin of a New Zealand white rabbit under an occlusive dressing for four hours. The skin was then observed for seven days for signs of irritation or corrosion. Immediate necrosis of the skin was observed following the application. Necrosis and scabs were apparent seven days following the exposure. It was therefore concluded that dichloro(methyl)silane is corrosive to the skin.

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