Registration Dossier

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

Hydrocarbons, C16-C22, n-alkanes, isoalkanes, <2% aromatics is not hazardous for human health with respect to skin irritation, eye irritation, acute toxicity (lethality or specific target organ toxicity following a single exposure), sensitisation, specific target organ toxicity following repeated exposures, reproductive toxicity, developmental toxicity, carcinogenicity and genetic toxicity.

The critical health effects are aspiration hazard (potential lung damage following accidental swallowing) and potential skin dryness or cracking following repeated dermal exposures. It is not possible to determine quantitative dose descriptors for these effects.

In the absence of adverse effects in acute and long-term systemic and reproductive studies it is not possible to determine DNEL values for systemic effects and risk characterisation is not necessary.

Qualitative risk characterisation is required based on the aspiration hazard and potential skin dryness and cracking.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

There were no adverse effects relevant for human hazard assessment up to the highest dose tested in the available studies for systemic effects. It is therefore not appropriate to quantify Derived No Effect Levels for humans, in accordance with the draft update to Chapter B.8 of REACH Technical Guidance: Guidance on information requirements and hazard assessment Part B.

Hydrocarbons, C16-C22, n-alkanes, isoalkanes, <2% aromatics is not hazardous for human health with respect to skin irritation, eye irritation, acute toxicity (lethality or specific target organ toxicity following a single exposure), sensitisation, specific target organ toxicity following repeated exposures, reproductive toxicity, developmental toxicity, carcinogenicity and genetic toxicity.

The critical health effects are aspiration hazard (potential lung damage following accidental swallowing) and potential skin dryness or cracking following repeated dermal exposures. It is not possible to determine quantitative dose descriptors for these effects.

In the absence of adverse effects in acute and long-term systemic and reproductive studies it is not possible to determine DNEL values for systemic effects and risk characterisation is not necessary.

Qualitative risk characterisation is required based on the aspiration hazard and potential skin dryness and cracking.

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