Registration Dossier
Registration Dossier
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EC number: 207-951-2 | CAS number: 502-72-7
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 December 2015 - 21 April 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- other: Reference to the validated analytical method used for quantification of the water samples.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- 0.604 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 8.5
- Remarks on result:
- other: Flowrate 24 mL/h. Mean of 10 samples. CV= 5.2%.
- Water solubility:
- 0.553 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 8.2
- Remarks on result:
- other: Flowrate 12 mL/h. Mean of 10 samples. CV= 6.0%.
- Key result
- Water solubility:
- 0.578 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 8.2 - <= 8.5
- Remarks on result:
- other: mean value (maximum difference=8.8%)
- Details on results:
- The coefficient of variation (CV) (n=10) was ≤ 30% at both flow rates. It demonstrated that the system was equilibrated at all flow rates.
The maximum difference on the mean values at both flow rates was ≤ 30%. The water solubility of the substance is given as the mean value of these measurements: 0.578 mg/L. - Conclusions:
- The water solubility at 20°C of the substance was determined to be 0.578 mg/L.
- Executive summary:
The water solubility was determined using the column elution method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840.
Quantification was performed by GC-MS-MS. The water solubility at 20°C of the substance was determined to be 0.578 mg/L. The pH of the aqueous samples was 8.2 -8.5.
Reference
No test substance was detected in the samples from the blank column.
Description of key information
The water solubility at 20°C of the substance was determined to be 0.578 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 0.578 mg/L
- at the temperature of:
- 20 °C
Additional information
Determined using the column elution method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840.
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