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EC number: 207-951-2 | CAS number: 502-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- May 12, 1981
- Deviations:
- yes
- Remarks:
- Observation period 72 hours
- Qualifier:
- according to guideline
- Guideline:
- other: EWG Directive 84/449/EWG, Amtsblatt der Europaeischen Gemeinschaften L 251, Jahrgang 27, 19.9.84 B.5 . Akute Toxizitaet - Augenreizung / 109
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclopentadecanone
- EC Number:
- 207-951-2
- EC Name:
- Cyclopentadecanone
- Cas Number:
- 502-72-7
- Molecular formula:
- C15H28O
- IUPAC Name:
- cyclopentadecanone
- Test material form:
- other: wax-like mass
- Details on test material:
- - State of aggregation: wax-like mass
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 6002
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- KFM (SPF-quality)
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, CH 4414 Fuellinsdorf, Switzerland
- Age at study initiation: 15-16 weeks
- Weight at study initiation: 2.4-2.8 kg
- Housing: individually in stainless steel cages equipped with an automatic cleaning and drinking system (Dipl. Ing. W. Ehret GmbH).
- Diet (e.g. ad libitum): pelleted standard Kliba 341, batch 14/B6 rabbit maintenance diet ("Kliba", Klingentalmuehle AG, 4303 Keiseraugst, Switzerland), ad libitum
- Water (e.g. ad libitum): community tap water from Itingen, ad libitum
- Acclimation period: three days under laboratory conditions after veterinary examination
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 40-70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: April 14, 1986 To: April 17, 1986
Test system
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g
- Concentration (if solution): 100% (pure substance) or 30% dilution
- Duration of treatment / exposure:
- Single instillation
- Observation period (in vivo):
- 1, 24, 48 and 72 hours post-administration
- Number of animals or in vitro replicates:
- 3 (2 males, 1 female)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not performed
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- 100% pure substance
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no corneal effects observed in any animal at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Remarks:
- 100% pure substance
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effects on iris observed in any animal at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- 100% pure substance
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- chemosis score
- Remarks:
- 100% pure substance
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours post-instillation
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- cornea opacity score
- Remarks:
- 30% dilution
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no corneal effects noted in any animal at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Remarks:
- 30% dilution
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no iris effects observed in any animal at any time point
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- 30% dilution
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.11
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours post-instillation
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects observed in any animal at any time point
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- 100% pure substance:
After 1 hour, erythema (general, severe in one animal) and ventral edema (slight in one animal) of the conjunctiva was observed in all three rabbits. Severe discharge and erythema of the sclera (slight in one animal) were observed in all animals. Furthermore, test article remains, partly white mass, were observed in one out of three animals.
After 24 hours, conjunctival and scleral erythema were observed in all animals.
After 48 and 72 hours, no abnormal changes were noted in any animal.
30% dilution:
After 1 hour, ventral conjunctival erythema was observed in 2 out of 3 animals. Furthermore, test article remains, ventral erythema of the sclera and slight discharge were observed in 1 out of 3 animals.
After 24 hours, slight, hardly perceptible erythema of conjunctivae and ventral erythema of the sclera, as well as test article remains were noted in one out of three animals.
After 48 and 72 hours, no abnormal changes were noted in any animal. - Other effects:
- - Lesions and clinical observations: in the area of application no discoloration of the cornea and conjunctivae was observed which could be related to the color to the test article.
- Other observations: the body weight gain of all rabbits was similar. Due to the results obtained, no macroscopic organ examination was indicated.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the reliable guideline study with rabbits, cyclopentadecanone administered as a pure substance and at 30% dilution was not irritating to rabbit eyes.
- Executive summary:
In a reliable study performed according to OECD Guideline 405, 0.1 g cyclopentadecanone was instilled into eyes of three rabbits either as a pure substance or at 30% dilution. The average scores over 24, 48 ad 72 hours in case of pure substance were 0 for corneal opacity, 0 for iritis, 0.33 for conjunctival erythema and 0 for chemosis. In case of 30% dilution, the average scores over 24, 48 and 72 hours were 0 for corneal opacity, 0 for iritis, 0.11 for conjunctival erythema and 0 for chemosis. All observed effects were fully reversible within max. 48 hours. Based on these results, classification of cyclopentadecanone for eye irritation is not required.
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