Registration Dossier
Registration Dossier
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EC number: 207-951-2 | CAS number: 502-72-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study predating GLP and modern guidelines, limited documentation, but sufficient to derive LD50 value
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Cyclopentadecanone was administered at the limit dose of 5000 mg/kg bw to 10 rats. Animals were observed for 14 days for mortality and clinical signs.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Cyclopentadecanone
- EC Number:
- 207-951-2
- EC Name:
- Cyclopentadecanone
- Cas Number:
- 502-72-7
- Molecular formula:
- C15H28O
- IUPAC Name:
- cyclopentadecanone
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 75-20
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10/dose (sex unspecified)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs - Statistics:
- Not applied.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no mortalities over the 14 days observation period.
- Clinical signs:
- No clinical signs were noted.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of the study, LD50 of cyclopentadecanone is > 5000 mg/kg bw.
- Executive summary:
In a study predating GLP and modern guidelines, cyclopentadecanone has been administered orally to a group of 10 rats of unspecified sex and strain at a limit dose of 5000 mg/kg bw. Animals were observed for 14 days for mortality and clinical signs. There were no deaths, and no clinical signs were noted. Based on the results of the study, the LD50 of cyclopentadecanone exceeds 5000 mg/kg bw.
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