Registration Dossier
Registration Dossier
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EC number: 203-910-8 | CAS number: 111-81-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The objective of the study was to evaluate the short term toxicity of test item methyl 10 -undecenoate to aquatic invertebrates. The method followed the OECD 202 guideline. Test organism was Daphia magna. The results were EC50-24 h of 2.7 mg/l, and EC50-48 h of 1.8 mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.8 mg/L
Additional information
The objective of the study was to evaluate the short term toxicity of test item methyl 10 -undecenoate to aquatic invertebrates. The method followed the OECD 202 guideline. Test organism was Daphia magna. The results were EC50-24 h of 2.7 mg/l, and EC50 -48 h of 1.8 mg/l.This study failed the validity criterion that at the test at least 80% test item concentration still should be present in the test medium, presumably due to the limited water solubility of the test item around the neutral pH range and due to hydrolysis effects. The test item concentrations at test end were found to be between 20 and 37% below the initial concentrations at test start. No geometric mean approach of test item concentartions was applied by the study director, as he reported the results based on initial concentrations.Assuming the test item concentrations at test end were being used for EC50 computations, which have been some 30% below the initial concentrations, thus the resulting EC50 likewise would be some 30% lower. In this worst case assumption, the now resulting EC50 -48 h still would be higher than 1.0 mg/l, which means in turn that still the same category 2 for acute environmental toxcity would apply. Therefore,the registrant would like to claim overall acceptability of the study.
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