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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Clinical allergy report, GLP and guidelines do not apply
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1977

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Test guideline
Qualifier:
no guideline required
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentaerythritol tetrakis(3-mercaptopropionate)
EC Number:
231-472-8
EC Name:
Pentaerythritol tetrakis(3-mercaptopropionate)
Cas Number:
7575-23-7
Molecular formula:
C17H28O8S4
IUPAC Name:
3-[(3-sulfanylpropanoyl)oxy]-2,2-bis({[(3-sulfanylpropanoyl)oxy]methyl})propyl 3-sulfanylpropanoate

Method

Type of population:
occupational
Ethical approval:
not applicable
Subjects:
- Number of subjects exposed: 3
- Sex: male
- Age: 54, 51, 41
- Race: not described
- Demographic information: printers
Clinical history:
- Symptoms, onset and progress of the disease: contact eczema on hands and fingers
- Exposure history: several months of work with a Letterflex machine
Route of administration:
dermal
Details on study design:
TYPE OF TEST(S) USED: patch test (epicutaneous test)

ADMINISTRATION
- Type of application: semiocclusive
- Description of patch: not described
- Vehicle / solvent: 100 % alcohol, toluene/ ol.olivae (1:1), MEK
- Concentrations: 5%
- Volume applied: not described
- Testing/scoring schedule: not described
- Removal of test substance: not described

EXAMINATIONS
- Grading/Scoring system: not described
- Statistical analysis: not described

Results and discussion

Results of examinations:
sensitising

NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 3/3

All three individuals strongly reacted to the Letterflex urethane photoprepolymer mixture upon patch testing.
The mixture was analysed and its individual components were subjected to a GPMT. PETMP was identified as a strong sensitizer and the responsible sensitizer in the Letterflex mixture.

Applicant's summary and conclusion

Conclusions:
PETMP was identified as the sensitizing component in the Letterflex urethane photoprepolymer mixture.

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