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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Clinical allergy report, GLP and guidelines do not apply
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1977

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Test guideline
Qualifier:
no guideline required
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentaerythritol tetrakis(3-mercaptopropionate)
EC Number:
231-472-8
EC Name:
Pentaerythritol tetrakis(3-mercaptopropionate)
Cas Number:
7575-23-7
Molecular formula:
C17H28O8S4
IUPAC Name:
3-[(3-sulfanylpropanoyl)oxy]-2,2-bis({[(3-sulfanylpropanoyl)oxy]methyl})propyl 3-sulfanylpropanoate

Method

Type of population:
occupational
Ethical approval:
not applicable
Subjects:
- Number of subjects exposed: 3
- Sex: male
- Age: 54, 51, 41
- Race: not described
- Demographic information: printers
Clinical history:
- Symptoms, onset and progress of the disease: contact eczema on hands and fingers
- Exposure history: several months of work with a Letterflex machine
Route of administration:
dermal
Details on study design:
TYPE OF TEST(S) USED: patch test (epicutaneous test)

ADMINISTRATION
- Type of application: semiocclusive
- Description of patch: not described
- Vehicle / solvent: 100 % alcohol, toluene/ ol.olivae (1:1), MEK
- Concentrations: 5%
- Volume applied: not described
- Testing/scoring schedule: not described
- Removal of test substance: not described

EXAMINATIONS
- Grading/Scoring system: not described
- Statistical analysis: not described

Results and discussion

Results of examinations:
sensitising

NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 3/3

All three individuals strongly reacted to the Letterflex urethane photoprepolymer mixture upon patch testing.
The mixture was analysed and its individual components were subjected to a GPMT. PETMP was identified as a strong sensitizer and the responsible sensitizer in the Letterflex mixture.

Applicant's summary and conclusion

Conclusions:
PETMP was identified as the sensitizing component in the Letterflex urethane photoprepolymer mixture.