Registration Dossier
Registration Dossier
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EC number: 231-472-8 | CAS number: 7575-23-7
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Clinical allergy report, GLP and guidelines do not apply
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- no
Test material
- Reference substance name:
- Pentaerythritol tetrakis(3-mercaptopropionate)
- EC Number:
- 231-472-8
- EC Name:
- Pentaerythritol tetrakis(3-mercaptopropionate)
- Cas Number:
- 7575-23-7
- Molecular formula:
- C17H28O8S4
- IUPAC Name:
- 3-[(3-sulfanylpropanoyl)oxy]-2,2-bis({[(3-sulfanylpropanoyl)oxy]methyl})propyl 3-sulfanylpropanoate
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not applicable
- Subjects:
- - Number of subjects exposed: 3
- Sex: male
- Age: 54, 51, 41
- Race: not described
- Demographic information: printers - Clinical history:
- - Symptoms, onset and progress of the disease: contact eczema on hands and fingers
- Exposure history: several months of work with a Letterflex machine - Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: semiocclusive
- Description of patch: not described
- Vehicle / solvent: 100 % alcohol, toluene/ ol.olivae (1:1), MEK
- Concentrations: 5%
- Volume applied: not described
- Testing/scoring schedule: not described
- Removal of test substance: not described
EXAMINATIONS
- Grading/Scoring system: not described
- Statistical analysis: not described
Results and discussion
- Results of examinations:
- sensitising
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 3/3
All three individuals strongly reacted to the Letterflex urethane photoprepolymer mixture upon patch testing.
The mixture was analysed and its individual components were subjected to a GPMT. PETMP was identified as a strong sensitizer and the responsible sensitizer in the Letterflex mixture.
Applicant's summary and conclusion
- Conclusions:
- PETMP was identified as the sensitizing component in the Letterflex urethane photoprepolymer mixture.
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