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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: sufficient documented for evaluation

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Radioallergosorbent testing with p-tolylmonoisocyanate in toluene diisocyanate workers
Author:
Butcher BT, O'Neil CEO, Reed NA, Salvaggio JE
Year:
1983
Bibliographic source:
Clinical Allergy 13, 31-34
Reference Type:
publication
Title:
Radioallergosorbent testing of toluene diisocyanate-reactive individuals using p-tolyl isocyanate antigen
Author:
Butcher BT, O'Neil CE, Reed MA, Salvaggio JE
Year:
1980
Bibliographic source:
J Allergy Clin Immunol 66, 213-216

Materials and methods

Type of sensitisation studied:
respiratory
Study type:
other: study with occupational exposed workers
Principles of method if other than guideline:
Sera from 149 occupationally exposed toluene diisocyanate (TDI) workers were tested by RAST with p-tolyl monoisocyanate human serum albumin (TMI-HSA)
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
622-58-8
IUPAC Name:
622-58-8

Method

Type of population:
occupational

Results and discussion

Results of examinations:
Of the seven positives, one had a history suggestive of TDI asthma and one had a rash which may have been TDI related. These results indicate that false positive RAST (radioallergosorbent testing) with TMA-HSA may occur in asymptomatic workers

Any other information on results incl. tables

Of the seven positives, one had a history suggestive of TDI asthma and one had a rash which may have been TDI related. These results indicate that false positive RAST (radioallergosorbent testing) with TMA-HSA may occur in asymptomatic workers

Applicant's summary and conclusion

Executive summary:

In this study, serum samples collected during a 5 -year prospective evaluation of workers manufacturing TDI were tested to determine whether occupational exposure to TDI stimulates production of specific IgE antibodies in asymptomatic individuals.

Of the seven positives, one had a history suggestive of TDI asthma and one had a rash which may have been TDI related. These results indicate that false positive RAST (radioallergosorbent testing) with TMA-HSA may occur in asymptomatic workers.