p-tolyl isocyanate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: secondary source

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1956

Report date:

1956

Materials and methods

Principles of method if other than guideline:

Six guinea pigs reveived per gavage a single dose in the range of of 800 - 1600 mg/kg bw p-tolylisocyanate. The animals were observed for mortality, weight and clinical signs.

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

p-tolyl isocyanate

EC Number:

210-743-4

EC Name:

p-tolyl isocyanate

Cas Number:

622-58-2

Molecular formula:

C8H7NO

IUPAC Name:

1-isocyanato-4-methylbenzene

Test animals

Species:

guinea pig

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

800 - 1600 mg/kg bw

No. of animals per sex per dose:

6 guinea pigs (totally)

Control animals:

not specified

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 800 - ca. 1 600 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

Symptoms: weekness

Time of death: 1-5 days

Applicant's summary and conclusion

Executive summary:

Six guinea pigs reveived per gavage a single dose in the range of of 800 - 1600 mg/kg bw p-tolylisocyanate. The animals were observed for mortality, weight and clinical signs. The animals showed to following symptoms: weekness. Time of death: 1 -5 days.

LD50 = approx. 800 - 1600 mg/kg bw