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EC number: 200-087-7 | CAS number: 51-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data have been obtained from secondary source.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Toxicological Profile for dinitrophenol
- Author:
- M. Olivia Harris, M.A; James J. Corcoran, Ph.D. (peer rewied by Dr. martin Alexander; Dr.Leon Koller; Dr.Norman Trieff)
- Year:
- 1 995
- Bibliographic source:
- U.S Department of Health and human Services, Public Health Service Agency for Toxic Substances and Disease Registry
- Reference Type:
- other: original reference
- Title:
- Analysis and kinetics of 2,4-dinitrophenol in tissues by capillary gas chromatography-mass spectrometry
- Author:
- Robert TA, Hagardorn AN.
- Year:
- 1 983
- Bibliographic source:
- J Chromatogr 276:77-84.
Materials and methods
- Principles of method if other than guideline:
- The half-time for absorption of 2,4-DNP following gavage administration of a single dose to mice was determined by a highly specific capillary gas chromatography (GC)-mass spectrometry (MS). Also serum and tissue levels of parent compound were quantitated by a highly specific capillary GC-MS method at 1-24 hours postdosing. Fractional absorption was not determined. Further details of method have not been specified.
Test material
- Reference substance name:
- 2,4-dinitrophenol
- EC Number:
- 200-087-7
- EC Name:
- 2,4-dinitrophenol
- Cas Number:
- 51-28-5
- Molecular formula:
- C6H4N2O5
- IUPAC Name:
- 2,4-dinitrophenol
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Duration and frequency of treatment / exposure:
- Single dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
22.5 mg/kg
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The half-time for absorption of 2,4-DNP following gavage administration was 0.5 hours.
Maximum values for the plasma concentration of 2,4-DNP were seen at 0.5 and 1.0 hours after dosing, giving additional evidence of rapid absorption. - Details on distribution in tissues:
- Pharmacokinetic analysis indicated that a two-compartment open model best characterized the disposition of 2,4-DNP in the serum, liver, and kidney of mice given a gavage dose.
At 1-24 hours postdosing, although concentrations of 2,4-DNP were much lower in liver and kidney than in serum, similar half-times for absorption (t1/2 = 0.50-0.62 hours) and for the fast (alpha) (t1/2 = 1.00-1.20 hours) phase of biphasic elimination in all 3 tissues were determined. However, terminal (beta) elimination phase from kidney was very slow (t1/2 = 76.2 hours) compared with the beta phase in liver (t1/2 = 8.7 hours) and in serum (t1/2 = 7.7 hours).
- Details on excretion:
- Half-times for the slow terminal elimination phases were 7.7 hours for serum, 8.7 hours for liver, and 76.2 hours for kidney.
Applicant's summary and conclusion
- Conclusions:
- Absorption: maximum values of of 2,4-DNP plasma concentration show evidence of a rapid absorption.
Distribution: concentrations of 2,4-DNP were much lower in liver and kidney than in serum.The similar half-times for absorption and biphasic elimination in all three tissues (except terminal elimination phase in kidney) indicated that rapid exchange of 2,4-DNP occurred among these sites. The authors suggested that the apparent persistence of 2,4-DNP in the kidney could be related to tissue binding of the compound.
Excretion: based on results, the authors suggested that the apparent persistence of 2,4-DNP in the kidney could be related to tissue binding of the compound. Half-times for the slow terminal elimination phases were 7.7 hours for serum, 8.7 hours for liver, and 76.2 hours for kidney. - Executive summary:
Data have been obtained from secondary source, that mentions Robert TA, Hagardorn AN. 1983. Analysis and kinetics of 2,4-dinitrophenol in tissues by capillary gas chromatography-mass spectrometry. J Chromatogr 276:77-84.
Absorption, distribution and excretion of 2,4 -dinitrophenol were studied in mice treated by gavage administration with a single dose of 22.5 mg/kg.
A highly specific capillary gas chromatography (GC)-mass spectrometry (MS) technique was used to measure serum concentrations of 2,4-DNP at 1, 3, 6, 12, and 24 hours after dosing. Further details of method have not been specified.
The data were best represented by a two-compartment open model, and the analysis was performed accordingly. Fractional absorption was not determined.
Absorption: the half-time for absorption of 2,4-DNP following gavage administration was 0.5 hours.
Maximum values for the plasma concentration of 2,4-DNP were seen at 0.5 and 1.0 hours after dosing, giving additional evidence of rapid absorption.
Distribution: serum and tissue levels of the parent compound were quantitated by a highly specific capillary GC-MS method at 1-24 hours postdosing. Concentrations of 2,4-DNP were much lower in liver and kidney than in serum. Similar half-times for absorption (t1/2 = 0.50-0.62 hours) and for the fast (alpha) (t1/2 = 1.00-1.20 hours) phase of biphasic elimination in all 3 tissues were determined.
However, terminal (beta) elimination phase from kidney was very slow (t1/2 = 76.2 hours) compared with the beta phase in liver (t1/2 = 8.7 hours) and in serum (t1/2 = 7.7 hours). The similar half-times for absorption and biphasic elimination in all three tissues (except terminal elimination phase in kidney) indicated that rapid exchange of 2,4-DNP occurred among these sites. The authors suggested that the apparent persistence of 2,4-DNP in the kidney could be related to tissue binding of the compound.
Excretion: pharmacokinetic analysis indicated that a two-compartment open model best characterized the disposition of 2,4-DNP in the serum, liver, and kidney of mice given a gavage dose. Serum and tissue levels of parent compound were quantitated by a highly specific capillary GC-MS method at 1-24 hours postdosing. Half-times for the slow terminal elimination phases were 7.7 hours for serum, 8.7 hours for liver, and 76.2 hours for kidney. The authors suggested that the apparent persistence of 2,4-DNP in the kidney could be related to tissue binding of the compound.
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