Registration Dossier
Registration Dossier
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EC number: 266-104-5 | CAS number: 66069-34-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A 96 hour acute toxicity to fish study was completed on the surrogate material Potassium Clavulanate according to EU Method C1 from the official journal of the European Communities. The test was conducted under static conditions. No mortality was observed throughout the study which gave an LC50 value of > 790 mg/L and a NOEC value of 790 mg/L. the measured concentrations were calculated to be 79% of the nominal concentration.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 790 mg/L
Additional information
Two 96 hour acute toxicity to fish studies were conducted on the surrogate material Potassium Clavulanate. Please see our read across proposal in section 13 for further details as to why read across is applicable.
There is not much difference between the two acute fish studies. Both studies have been conducted according to GLP guidelines, both have been conducted at the same laboratory (Brixham Environmental Laboratory, Zeneca Limited). Both studies were tested for 96 hours under static conditions. The major difference between the two studies was that one of the studies was conducted on the rainbow trout and the other study was conducted on the bluegill sunfish. We have selected the study on the bluegill sunfish as the key study because out of the two studies available this was determined to have the worst case result and the lowest EC50 value.
The results of the two studies have been shown below:
POTASSIUM CLAVULANATE: Determination of acute toxicity to bluegill sunfish (Lepomis macrochirus)
A nominal concentration of 1000 mg/L was used for the study. The measured concentrations were calculated to be 79% of the nominal concentrations, which means the 96 hour LC50 was > 790 mg/L and the 96 hour NOEC = 790 mg/L.
Potassium Clavulanate: Determination of acute toxicity to rainbow trout (oncorhynchus mykiss)
The nominal concentration tested within the study was 1000mg/L. The mean measured exposure concentration of the test substance was 96% of the nominal exposure concentration, which has provided the following mean measured results:
The 96 hour LC50 values were determined to be > 960 mg/L-1
The 96 hour NOEC = 960 mg/L-1.
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