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EC number: 213-382-0 | CAS number: 941-69-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD 403 & GLP. Test substance is micronized from this substance. The commercial product (>355 um) has practically no micronized particle size (<10 um .Test substance is micronized from this substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N-phenylmaleimide
- EC Number:
- 213-382-0
- EC Name:
- N-phenylmaleimide
- Cas Number:
- 941-69-5
- Molecular formula:
- C10H7NO2
- IUPAC Name:
- 1-phenyl-2,5-dihydro-1H-pyrrole-2,5-dione
- Details on test material:
- Purity:>99.9%
Test substance is micronized from this substance.
The commertial product (>355 um) has practically no micronized particle size (<10 um .
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: atomise the aceton/water (80/20) solution
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 0.009, 0.016, 0.033, 0.033, 0.044, 0.183 mg/l
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.034 mg/L air
- 95% CL:
- > 0.031 - < 0.037
- Exp. duration:
- 4 h
- Mortality:
- Conc (mg/L) M F Total
0.009 0/5 0/5 0/10
0.016 0/5 0/5 0/10
0.033 4/5 1/5 5/10
0.044 4/5 4/5 8/10
0.183 5/5 5/5 10/10 - Clinical signs:
- other: The signs seen during exposure were considered to be partial closing of the eyes, adoption of a hunched body posture, opening of the mouth during inspiration and exaggerated respiratory movement.
- Body weight:
- There were moderate to marked decreases of bodyweight or reductions in the rate of bodyweight gain for up to 7 days following exposure to this test substance.
- Gross pathology:
- The findings for rats that died as a result of exposure to this test substance were typified by congestion of the lungs and/or distension of the gastro-intestinal tract. The latter is commonly seen in rats that die as a result of respiratory difficulties and is due to swallowing of air during attempts to breathe.
- Other findings:
- Other findings were considered to be within the normal background ranges, and of no toxicological importance.
There were no clear evidence of a sex difference in mortaity due to inhalation of this test substance.
Any other information on results incl. tables
Conc. Date of death (M/F)
Conc. mg/L | 0 h | 1h | 4 h | 1 d | 2 d | 8 d | 14 d |
0.033 | 0/0 | 0/0 | 0/0 | 4/1 | 4/1 | 4/1 | 4/1 |
0.044 | 0/0 | 0/0 | 1/0 | 4/3 | 4/3 | 4/4 | 4/4 |
0.183 | 0/0 | 2/1 | 2/4 | 5/5 | 5/5 | 5/5 | 5/5 |
Applicant's summary and conclusion
- Interpretation of results:
- other: This data is not effective to this product due to this product particle is not micronised.
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- LC = 0.034 mg/L. Test substance is micronized from this substance. The results show that on average, approximately 80% of the PMI present in the chamber
atomosphere was in the form of particle of respirable size (< 5.5 um aerodynamic diameter).
The commertial product (>295 um) has practically no micronized particle size (<10 um) . - Executive summary:
In an acute inhalation toxicity study, groups of young adult albino rats (Sprague-Dawley origin) , 5/sex were exposed by inhalation route to PMI (>99.5% provided by NIPPON SHOKUBAI 7Y09) in acetone/water (80/20) for 4 hours to whole body at concentrations of 0, 0.009, 0.016, 0.033, 0.044, 0.183 mg/L. Animals then were observed for 14 days.
LC50 Combined = 0.034 mg/L (standard error : 0.0033 mg/L)
PMI is classified as the category 1 in accordance with GHS for acute inhalation toxicity study.
The commertial product (>295 um) has not including any respirable fraction, practically the rsik by inahalation is very low .
However, we should consider the DNEL for inhalation for workers because of any accidental release of this product at polymer manufacturers plant site.
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