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EC number: 213-382-0 | CAS number: 941-69-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The original sources of test substances in A1) and B1) tests are Nippon Shokubai and the original sources in A2) and B2) tests are other company. So, the result may be affected by the impurities in the test substance. However as this cannot be definitively proved, an appropriate in-vivo somatic cell genotoxicity study is being performed as triggered by REACH Annex VIII Section 8.4 Column 2.
Toxicity test |
Result |
Remarks |
Source of test substance Purity(%) |
Test Guideline |
A1) bacterial reverse mutation assay (e.g. Ames test) |
negative |
10 ug/plate: where antibacterial activity were shown |
Nippon Shokubai>99.9% |
JAPAN: Guidelines for Screening Mutagenicity Testing Of Chemicals |
A2) bacterial reverse mutation assay (e.g. Ames test) |
Positive atTA98 and TA1537 with the non-activation method (-S9) . |
Confirmation test:6 ug/plate or more are positive reaction |
Daihachi Chemical Industry>99.2% |
JAPAN: Guidelines for Screening Mutagenicity Testing Of Chemicals |
B1) in vitro mammalian chromosome aberration test |
negative |
test concentration: <= 5 ug/plate |
Nippon Shokubai>99.9% |
OECD 473 |
B2) in vitro mammalian chromosome aberration test |
Positive at the additional high concentration test without metabolic activation
|
This positive result is considered as equivocal due to these positive findings generated only at fighly toxic/cytotoxic concentrations. (REACH Guidance R.7a R.7.4.1) |
Daihachi Chemical Industry>99.2% |
OECD 473 |
C) in vivo micronucleus study |
Negative at toxic doses |
- | Nippon Shokubai>99.8% |
OECD 474 |
Short description of key information:
Genetic toxicity data (Amest and Chromosome aberration) show negative with the test sample provided by NIPPON SHOKUBAI.
Genetic toxicity data (Amest and Chromosome aberration) show positive with the test sample provided by Daihachi Chemical. The positive result is considered as equivocal due to these positive findings generated only at highly toxic/cytotoxic concentrations. (REACH Guidance R.7a R.7.4.1)
As recommended in the REACH Guidance R.7a Table R.7.7-1, appropriate in vivo mutagenicity studies has been considered in case of another submitter whose purity is different from above 2 samples. The in vivo micronucleus study showed a negative result.
Therefore, PMI is considered as non-mutagenic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The substance is not considered as mutagenic, and is therefore not classified in accordance with GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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