Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
3.1 µg/L
Assessment factor:
1 000
PNEC freshwater (intermittent releases):
31 µg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.31 µg/L
Assessment factor:
10 000

STP

Hazard assessment conclusion:
no hazard identified

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
17.1 µg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
1.7 µg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
1.6 µg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

The following data for aquatic toxicity and environmental fate are available:

  • Biodegradability: the test item is not readily biodegradable
  • Log Kow = -1.21
  • Toxicity to fish: LC50-96h = 20 mg/L
  • Short term toxicity to aquatic invertebrates: 48h-EC50 = 3.1 mg/L
  • Toxicity to aquatic algae: ErC50-72h= 30 mg/L & ErC10-72h= 18 mg/L

Regarding these data,4-methyl-3-thiosemicarbazideshould be classified as follows: 

  • According to the Directive 67/548/EC:R51/53
  • According to CLP: chronic toxicity category 2