Registration Dossier
Registration Dossier
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EC number: 200-353-2 | CAS number: 57-88-5
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
According to Column 2 of REACH Annex IX, long-term toxicity testing shall be proposed if the chemical safety assessment indicates the need to investigate further the effects on aquatic organisms. Based on the chemical safety assessment (section 13), there is no need to further investigate long-term toxicity.
Key value for chemical safety assessment
Additional information
Based on the approach taken in the chemical safety assessment, there is no need to investigate long-term toxicity to aquatic invertebrates.
Two supporting publications show that arthropods lack the ability to synthesize cholesterol and other sterols de novo and therefore have to acquire these essential compounds from their diet. Cholesterol is therefore the limiting factor for growth and reproduction. Addition of cholesterol to their diets increase the growth and clutch sizes significantly.
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