Triisotridecyl benzene-1,2,4-tricarboxylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Study period:

3 - 25 Jul 1991

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: GLP-Guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1991

Report date:

1991

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

lack of details on test substance

GLP compliance:

yes (incl. QA statement)

Remarks:

The department of health and social security of the government of the United Kingdom

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters

EC Number:

304-780-6

EC Name:

1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters

Molecular formula:

C36H60O6 to C42H72O6

IUPAC Name:

1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters, branched and linear

Details on test material:

- Name of test material (as cited in study report): only trade name given
- Lot No.: 293
- Date received: June 5th, 1991
- Physical state: very pale straw-coloured slightly viscous liquid
- Storage conditions: room temperature
- Analytical purity: no data
- Specific Gravity: 0.954

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Ltd., Kent, UK
- Age at study initiation: 5-8 weeks
- Weight at study initiation: 152-165 g (males), 142-154 g (females)
- Fasting period before study: yes, overnight
- Housing: solid-floor polypropylene cages with sawdust bedding in groups of up to five by sex.
- Diet: Rat and Mouse Expanded Diet No. 1, Special Diet Services Ltd., Essex, UK., ad libitum
- Water: mains drinking water, ad libitum
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 24
- Humidity (%): 47 - 67
- Air changes (per hr): approx. 15
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 2.1 mL/kg

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of application and once daily thereafter.
- Frequency of weighing: on days 0, 7 and 14.
- Necropsy of survivors performed: yes (external examination and opening of the abdominal and thoracic cavities)

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality occured during the study period.

Clinical signs:

other: No clinical signs of toxicity were observed up to the end of the 14-day observation period.

Gross pathology:

Necropsy and histopathological examination revealed no substance-related findings.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

CLP: not classified
DSD: not classified