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EC number: 700-483-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute toxicity: oral: Wil Research Laboratories, Inc. Acute Oral Toxicity Study in Albino Rats with CR-39 (479-768) (1981); GLP; comparable to the OECD guideline 401.
Acute toxicity: dermal: Wil Research Laboratories, Inc. Acute Dermal Toxicity Study in Albino Rabbits with CR-39 (1971); comparable to the OECD guideline 402.
Acute toxicity: inhalation: Industrial BIO-TEST Laboratories, Inc. Acute vapor inhalation toxicity study with CR-39, 62310-31-151-1006 in albino rats (1971); comparable to the OECD guideline 403.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 515 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- discriminating conc.
- Value:
- 730 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 11 430 mg/kg bw
Additional information
Since RAV 7NG contains as main ingredient 'diallyl 2,2'oxydiethyl dicarbonate' and experimental data are lacking for RAV 7NG, the experimental data from 'diallyl 2,2'oxydiethyl dicarbonate' were used in a read-across approach.
Justification for read-across from supporting substance RAV 7AT (diallyl 2,2'-oxydiethyl dicarbonate; CAS 142-22-3; EC 205-528-7): about 70 % of RAV 7NG (EC 700-483-4) consists of components that can be found in the commercial ADC grades known as RAV 7AT, Nouryset 200 and CR39. Merely from comparing the similar production processes of these two substances it is apparent that RAV 7AT and RAV 7NG are closely related to each other. Finally, the physical-chemical, toxicological and ecotoxicological properties of RAV 7NG and RAV 7AT are almost equal and as a result, read across is justified.
Acute oral toxicity of carbonic acid, oxydiethylene diallyl ester to rats is moderate. The study " Acute Oral Toxicity Study in Albino Rats with CR-39 (479-768)" (dated 1981 -10 -22) was chosen as the key study for acute oral toxicity assessment because of its GLP compliance, a clear dose dependent response (four dose levels tested) and LD50 which was calculated for both sexes.Acute dermal toxicity to rabbits is low. When CR-39 was administered dermally at one dose level of 10 mL/kg bw to the nonabraded skin of 8 New Zealand White rabbits (4 males and 4 females), signs of systemic toxicity occurred (anorexia, adipsia, emaciation and decreased defecation) during the post dose observation period of 14 days. Three of eight animals were found dead on day 2 of the study. Positive gross pathologic findings were observed in four of eight of the test animals. From the data presented in the report the LD50 of CR-39 is greater than 10 mL/kg bw (11,430 mg/kg
No acute inhalation toxicity LC50 level could be established because of one dose level tested with only 1 hour of exposure.
Justification for classification or non-classification
The classification is warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulations No 1272/2008.
DSD:Xn, R22; Harmful if swallowed;
GHS:Acute tox.oral Cat. 4
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