Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-483-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Since RAV 7NG contains as main ingredient 'diallyl 2,2'oxydiethyl dicarbonate' and experimental data are lacking for RAV 7NG, the experimental data from 'diallyl 2,2'oxydiethyl dicarbonate' were used in a read-across approach.
Justification for read-across from supporting substance RAV 7AT (diallyl 2,2'-oxydiethyl dicarbonate; CAS 142-22-3; EC 205-528-7): about 70 % of RAV 7NG (EC 700-483-4) consists of components that can be found in the commercial ADC grades known as RAV 7AT, Nouryset 200 and CR39. Merely from comparing the similar production processes of these two substances it is apparent that RAV 7AT and RAV 7NG are closely related to each other. Finally, the physical-chemical, toxicological and ecotoxicological properties of RAV 7NG and RAV 7AT are almost equal and as a result, read across is justified.
In the "Delayed Contact Hypersensitivity Study In Guinea Pigs of CR-39 Monomer" (dated 1979-02-15) guinea pigs (10/sex) were dosed with 0.4 mL of carbonic acid, oxydiethylene diallyl ester to shaved intact skin under occluded conditions for 6 hours. Patches were reapplied to the same site of test animals once a week for a total of three applications. After a 2-week rest period, a fresh application site was challenged with 0.4 mL of the test substance as described previously. During the primary challenge, all 20 animals did not show any irritation at the 24- and 48-hour readings.Carbonic acid, oxydiethylene diallyl ester was not a skin sensitizer in guinea pigs.
Migrated from Short description of key information:
The "Delayed Contact Hypersensitivity Study In Guinea Pigs of CR-39 Monomer" (dated 1979-02-15) was performed prior to the adoption of the GLP regulations as well as OECD Guidelines.
Justification for classification or non-classification
- Skin sensitisation: the test substance was not a skin sensitizer in guinea pigs and rabbits ==>
The classification is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulations No 1272/2008.
- Respiratory sensitisation: no data
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
