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Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Since RAV 7NG contains as main ingredient 'diallyl 2,2'oxydiethyl dicarbonate' and experimental data are lacking for RAV 7NG, the experimental data from 'diallyl 2,2'oxydiethyl dicarbonate' were used in a read-across approach.

Justification for read-across from supporting substance RAV 7AT (diallyl 2,2'-oxydiethyl dicarbonate; CAS 142-22-3; EC 205-528-7): about 70 % of RAV 7NG (EC 700-483-4) consists of components that can be found in the commercial ADC grades known as RAV 7AT, Nouryset 200 and CR39. Merely from comparing the similar production processes of these two substances it is apparent that RAV 7AT and RAV 7NG are closely related to each other.  Finally, the physical-chemical, toxicological and ecotoxicological properties of RAV 7NG and RAV 7AT are almost equal and as a result, read across is justified.

In the "Delayed Contact Hypersensitivity Study In Guinea Pigs of CR-39 Monomer" (dated 1979-02-15) guinea pigs (10/sex) were dosed with 0.4 mL of carbonic acid, oxydiethylene diallyl ester to shaved intact skin under occluded conditions for 6 hours. Patches were reapplied to the same site of test animals once a week for a total of three applications. After a 2-week rest period, a fresh application site was challenged with 0.4 mL of the test substance as described previously. During the primary challenge, all 20 animals did not show any irritation at the 24- and 48-hour readings.

Carbonic acid, oxydiethylene diallyl ester was not a skin sensitizer in guinea pigs.


Migrated from Short description of key information:
The "Delayed Contact Hypersensitivity Study In Guinea Pigs of CR-39 Monomer" (dated 1979-02-15) was performed prior to the adoption of the GLP regulations as well as OECD Guidelines.

Justification for classification or non-classification

- Skin sensitisation: the test substance was not a skin sensitizer in guinea pigs and rabbits ==>

The classification is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulations No 1272/2008.

- Respiratory sensitisation: no data

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