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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

The toxicity of 1-amino-4-chlorobenzene towards the growth of Tetrahymena pyriformis was investigated with a test duration of 24 h (Yoshioka, 1985). Tests were carried out under sterile conditions and evaluated on the basis of cell counting. On the basis of these conditions, an EC50 of 10 mg/L was determined.
4-Chlorophenyl isocyanate is know to rapidly hydrolyse forming 1-amino-4-chlorobenzene as only hydrolysis product with a half-live of 7.3 h. With respect to a test duration of 24 h, it can be assumed that observed effects are rather caused by the hy-drolysis product than by the parent substance. Thus, the effect of 1-amino-4-chlorobenzene was chosen to characterize the ecotoxicological potential of 4-chlorophenyl isocyanate towards microorganisms.

Key value for chemical safety assessment

EC50 for microorganisms:
10 mg/L

Additional information