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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only one dose applied

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960
Report date:
1960

Materials and methods

Principles of method if other than guideline:
Method: other: oral application of 100 mg/kg of an oily solution (1%) to rats on 14 consecutive working days
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chlorophenyl isocyanate
EC Number:
203-176-9
EC Name:
4-chlorophenyl isocyanate
Cas Number:
104-12-1
Molecular formula:
C7H4ClNO
IUPAC Name:
1-chloro-4-isocyanatobenzene
Details on test material:
IUCLID4 Test substance: other TS: p-chlorophenyl isocyanate, purity >99%

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 1 % solution in oil (no further data)
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
14 working days
Frequency of treatment:
once per day
Doses / concentrations
Remarks:
Doses / Concentrations:
100 mg/kg bw
Basis:
actual ingested
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
Post-exposure period: ca. 4 weeks

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
100 mg/kg bw/day (nominal)
Sex:
male

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
no recognizable effects

Applicant's summary and conclusion

Executive summary:

method: oral application of 100 mg/kg of an oily solution (1%) to rats on 14 consecutive working days

result: no recognizable effects