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EC number: 203-176-9 | CAS number: 104-12-1
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only one dose applied
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
- Principles of method if other than guideline:
- Method: other: oral application of 100 mg/kg of an oily solution (1%) to rats on 14 consecutive working days
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorophenyl isocyanate
- EC Number:
- 203-176-9
- EC Name:
- 4-chlorophenyl isocyanate
- Cas Number:
- 104-12-1
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-4-isocyanatobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: p-chlorophenyl isocyanate, purity >99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1 % solution in oil (no further data)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 working days
- Frequency of treatment:
- once per day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: ca. 4 weeks
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 100 mg/kg bw/day (nominal)
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
no recognizable effects
Applicant's summary and conclusion
- Executive summary:
method: oral application of 100 mg/kg of an oily solution (1%) to rats on 14 consecutive working days
result: no recognizable effects
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