Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The test substance was found irritating to skin in the key study which was a 4 hour semi-occlusive exposure, conducted according to the appropriate EU guideline (Rees 1996; rel 1). The key study for eye irritation reports a mean 24+48+72 hour score for iritis of 1 in all test animals, and scores for conjunctivitis and corneal opacity of 2 (Rees 1996; rel 1).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

The most recent, high reliability studies were selected as key information. A supporting study for skin irritation was also available (Cassidy&Clark, 1978; rel 2), which was in accordance with the key findings, although it was performed under non-standard conditions (24 hour occluded exposure). In addition, a supporting study for skin irritation was read across from 1 -decanol (Kaestner,1977; rel 2) which is a comparative study that demonstrates the increased sensitivity of rabbit as a test species compared to human. The read across is taken into consideration in the classification decision.

The supporting study for eye irritation (Cassidy& Clark, 1978; rel 2) found the test substance not irritating to eye.

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

Based on the available information and in accordance with CLP (EC regulation 1272/2008) alcohols C7-9 linear and branched are classified as a category 2 irritant to the eye. No classification is proposed for skin irritation based on a category trend of lack of irritant effects in man despite positive data from animal studies.