Registration Dossier

Diss Factsheets

Administrative data

Description of key information

The test substance was found irritating to skin in the key study which was a 4 hour semi-occlusive exposure, conducted according to the appropriate EU guideline (Rees 1996; rel 1). The key study for eye irritation reports a mean 24+48+72 hour score for iritis of 1 in all test animals, and scores for conjunctivitis and corneal opacity of 2 (Rees 1996; rel 1).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

The most recent, high reliability studies were selected as key information. A supporting study for skin irritation was also available (Cassidy&Clark, 1978; rel 2), which was in accordance with the key findings, although it was performed under non-standard conditions (24 hour occluded exposure). In addition, a supporting study for skin irritation was read across from 1 -decanol (Kaestner,1977; rel 2) which is a comparative study that demonstrates the increased sensitivity of rabbit as a test species compared to human. The read across is taken into consideration in the classification decision.

The supporting study for eye irritation (Cassidy& Clark, 1978; rel 2) found the test substance not irritating to eye.

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

Based on the available information and in accordance with CLP (EC regulation 1272/2008) alcohols C7-9 linear and branched are classified as a category 2 irritant to the eye. No classification is proposed for skin irritation based on a category trend of lack of irritant effects in man despite positive data from animal studies.