Registration Dossier
Registration Dossier
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EC number: 266-417-7 | CAS number: 66587-56-2
Endpoint summary
Administrative data
Description of key information
The test substance was found irritating to skin in the key study which was a 4 hour semi-occlusive exposure, conducted according to the appropriate EU guideline (Rees 1996; rel 1). The key study for eye irritation reports a mean 24+48+72 hour score for iritis of 1 in all test animals, and scores for conjunctivitis and corneal opacity of 2 (Rees 1996; rel 1).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The most recent, high reliability studies were selected as key information. A supporting study for skin irritation was also available (Cassidy&Clark, 1978; rel 2), which was in accordance with the key findings, although it was performed under non-standard conditions (24 hour occluded exposure). In addition, a supporting study for skin irritation was read across from 1 -decanol (Kaestner,1977; rel 2) which is a comparative study that demonstrates the increased sensitivity of rabbit as a test species compared to human. The read across is taken into consideration in the classification decision.
The supporting study for eye irritation (Cassidy& Clark, 1978; rel 2) found the test substance not irritating to eye.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the available information and in accordance with CLP (EC regulation 1272/2008) alcohols C7-9 linear and branched are classified as a category 2 irritant to the eye. No classification is proposed for skin irritation based on a category trend of lack of irritant effects in man despite positive data from animal studies.
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