Registration Dossier
Registration Dossier
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EC number: 266-417-7 | CAS number: 66587-56-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The multi-constituent alcohol identified as “Alcohols C7-9 linear and branched” includes the following mixture:
Alcohols C6-12 type C: >80% linear; > 95% C7/8/9 [range C6-C10]; even & odd (CAS 68603-15-6).
The key study was performed to GLP according to OECD guideline 406 using the guinea-pig maximisation test method. The test material (Linevol 79) was diluted in propylene glycol and used for induction at 50% intradermal and 50% occlusive epicutaneous; the challenge applications were 5 and 30% occlusive epicutaneous. Erythema or eschar were seen in 19/20 test and 8/10 control animals 48 hours after challenge but this was attributed solely to primary irritation (Rees 1996c).
The supporting study was performed prior to the introduction of GLP using a protocol similar to that of OECD guideline 406 using the guinea-pig maximisation test method. Corn oil was used as the vehicle for the test material (Linevol 79) and induction applications were 0.1% intradermal and 100% occlusive epicutaneous; challenge application was 50% occlusive epicutaneous. No skin reactions were seen after challenge (Cassidy & Clark 1978b).
The test material was not a skin sensitiser under the conditions of these tests. The absence of sensitisation for other tested alcohols supports the view that these chemicals are not skin sensitisers.
Migrated from Short description of key information:
In two reliable studies, conducted according to (or similar to) OECD guideline 406, Linevol 79 was not a skin sensitiser in the guinea pig maximisation test (Cassidy & Clark 1978b, Rees 1996c).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The test material contains no structural groups suggestive of respiratory sensitisation and, together with the lack of skin sensitising potential, it is unlikely to be a respiratory sensitiser.
Migrated from Short description of key information:
no data
Justification for classification or non-classification
Based on the available data, Alcohols C7-9 linear and branched would not be classified as a skin or respiratory sensitiser under Regulation (EC) No. 1272/2008 (CLP) or Directive 67/548/EEC (DSD). Tests on similar substances included in this category are also supportive of these results, which do not warrant classification for sensitisation under DSD or GHS criteria.
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