Registration Dossier

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

The most sensitive organism regarding exposure to 1 -(dimethylamino)propan-2 -ol was Scenedesmus subspicatus (EC50 (72 h) = 77.4 mg/L) followed by Daphnia magna (EC50 (48 h) = 79 mg/L, whereas fish were less sensitive to the substance (Leuciscus idus LC50 (96 h) = 148 mg/L). The effect on aquatic organisms may in part be due to pH changes caused by 1-(dimethylamino)propan-2 -ol.

Short-term toxicity to fish:

With high probability acutely not harmful to fish.

One toxicity test with fish is available for 1 -(dimethylamino)propan-2 -ol. In a static system established according to DIN 38412 part 15 testing the toxicity of the substance to Leuciscus idus the determined LC50 was 148 mg/L (geom. mean) after 96 hours (BASF AG, 1989). However, the observed results are probably due to changes in pH values caused by 1-(dimethylamino)propan-2-ol as no mortality was observed in a pH-adjusted sample of 1000 mg/L. The test concentration were not analytically verified, but are assumed to be stable over the test period.

Long-term toxicity to fish:

In Annex IX of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on aquatic organisms.

According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or CLP-Regulation (EC) No 1272/2008 or is assessed to be a PBT or vPvB.

The hazard assessment of the 1-(dimethylamino)propan-2-ol reveals neither a need to classify the substance as dangerous for the environment, nor is it a PBT or vPvB substance.

Therefore, and for reasons of animal welfare, a long-term toxicity study in fish is not provided.

 

Short-term toxicity to aquatic invertebrates:

Acutely harmful to aquatic invertebrates.

An EC50 of 79 mg/L was determined in a study testing the toxicity of 1 -(dimethylamino)propan-2 -ol to Daphnia magna conducted according to guideline DIN 38412, part L11 (BASF AG 1989). The effect of the substance on the mobility of D. magna is probably in part due to pH changes caused by the substance. In a parallel test with a neutralised sample of the highest concentration (580 mg/L) the toxicity of the test item was reduced as after 48 h the immobilisation was 50% compared to 100% in the not-neutralised sample. Moreover, the effects were delayed in time as only 5% of the daphnids were immobilised in the neutralised 580 mg/L sample while in the not-neutralised sample all daphnids were immobilised already after 3 h. The test item concentrations were not analytically verified, but are assumed to be stable.

Long-term toxicity to aquatic invertebrates:

In Annex IX of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on aquatic organisms.

According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or CLP-Regulation (EC) No 1272/2008 or is assessed to be a PBT or vPvB.

The hazard assessment of 1-(dimethylamino)propan-2-ol reveals neither a need to classify the substance as dangerous for the environment, nor is it a PBT or vPvB substance.

Therefore, and for reasons of animal welfare, a long-term toxicity study on aquatic invertebrates is not provided.

 

Toxicity to aquatic algae and plants:

With high probability acutely not harmful to aquatic algae.

In a guideline test on the toxicity of 1-(dimethylamino)propan-2 -ol to Scenedesmus subspicatus an ErC50 (72 h) of 77.4 mg/L was detected (BASF AG, 1989). The inhibition of algal growth by 1-(dimethylamino)propan-2-ol was reduced by adjusting the pH in the test system. A pH-adjusted sample with 250 mg/L of the test substance was tested in addition. At 72 hours, a growth inhibition of 33.2% was observed in this sample (compared to 100% in the non-adjusted sample with 250 mg/L test substance). Thus, the observed growth inhibition is partly due to an increase in pH caused by the test substance. The test item concentrations were not analytically verified, but are assumed to be stable.

Toxicity to microorganisms:

The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.

One study on the toxicity of 1-(dimethylamino)propan-2-ol to microorganisms is available. In a guideline study conducted in compliance with OECD 209 an EC20 of > 1000 mg/L was determined after 30 minutes (BASF AG, 1989; report no. 08G0403/053290).