1-(dimethylamino)propan-2-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptabel for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1964

Report date:

1964

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

12 May 1981

Principles of method if other than guideline:

Method: BASF-Test: Test was performed in principle as described in OECD Guideline 403.
The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20°C). 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glassdisc in a glass cylinder for 8h. The documentation of clinical signs was performed over a period of 7 days. In order to verify the results, the test was repeated once.

GLP compliance:

no

Test type:

other: Inhalation-risk test (IRT)

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-(dimethylamino)propan-2-ol

EC Number:

203-556-4

EC Name:

1-(dimethylamino)propan-2-ol

Cas Number:

108-16-7

Molecular formula:

C5H13NO

IUPAC Name:

1-(dimethylamino)propan-2-ol

Test material form:

liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): Dimethyl-isopropanolamin
- Physical state: liquid
no further data

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

not specified

Remarks on duration:

3, 10 or 30 minutes

Concentrations:

Saturated dimethyl-isopropanolamin atmosphere.
Using the vapour pressure of 11.7 hPa at 20 °C and the molecular weight of 103.2 g/mol, a theoretical saturated vapour concentration of 49.6 mg/L can be calculated.

No. of animals per sex per dose:

3-6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7days
- Frequency of observations and weighing: observations: daily; weighing: at the beginning and end of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight (group only, no single animal weights)

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Exp. duration:

3 min

Remarks on result:

other: no deaths were observed when exposed to the test substance for 3 minutes

Effect levels 2

Sex:

male/female

Exp. duration:

10 min

Remarks on result:

other: 1/12 animals died when exposed to the test substance for 10 minutes

Effect levels 3

Sex:

male/female

Exp. duration:

30 min

Remarks on result:

other: 6/6 animals died when exposed to the test substance for 30 minutes

Mortality:

0/12 animals died when exposed for 3 min
1/12 animals died when exposed for 10 min
6/6 animals died when exposed for 30 min

Clinical signs:

other: attempts to escape, severe irritation of the mucous membrane, dyspnoea, blood incrusted nose

Body weight:

30 min: group mean: ca. 171 g at the beginning of the study, no body weights taken at the end of the study due to the death of the animals
10 min: group mean: ca. 164 g at the beginning of the study, ca. 208 g at the end of the study
3 min: group mean: ca. 179 g at the beginning of the study, ca. 165 g at the end of the study

Gross pathology:

sacrificed animals: organs without findings
died animals: greyish-brown incrustation in the nasal area