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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented study report which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report date:
1964

Materials and methods

Principles of method if other than guideline:
other: BASF-Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(dimethylamino)propan-2-ol
EC Number:
203-556-4
EC Name:
1-(dimethylamino)propan-2-ol
Cas Number:
108-16-7
Molecular formula:
C5H13NO
IUPAC Name:
1-(dimethylamino)propan-2-ol
Test material form:
liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Dimethyl-isopropanolamin

Test animals

Species:
mouse
Strain:
other: Hannover-mouse
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
0.1, 0.125, 0.16, 0.2, 0.4, 1.6 mL/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 150 mg/kg bw
Based on:
test mat.
Sex:
male/female
Dose descriptor:
LD50
Effect level:
0.18 mL/kg bw
Based on:
test mat.
Remarks on result:
other: original value
Mortality:
0/10 animals died at 0.1 mL/kg bw
1/10 animals died at 0.125 mL/kg bw
4/10 animals died at 0.16 mL/kg bw
7/10 animals died at 0.2 mL/kg bw
9/10 animals died at 0.4 mL/kg bw
5/5 animals died at 1.6 mL/kg bw
deaths occured within day 1-8
Clinical signs:
Apathy, staggering, dyspnoea, slight spasms and late deaths
Body weight:
no data
Gross pathology:
Animals that died during the study: slight irritation at injection site
Animals that were sacrificed at the end of the study: no findings

Applicant's summary and conclusion