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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation: aquatic / sediment
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two bioaccumulation studies as-
WoE 2. and WoE 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fish
Route of exposure:
aqueous
Test type:
not specified
Water / sediment media type:
not specified
Reference substance (positive control):
not specified
Details on estimation of bioconcentration:
WoE 2:
BASIS FOR CALCULATION OF BCF
- Result based on calculated log Pow of: 3.28 (estimated value)

WoE 3:
BASIS FOR CALCULATION OF BCF
- Result based on calculated log Pow of: 8.69(estimated value)
Key result
Type:
BCF
Value:
> 66 - < 500 dimensionless
Basis:
whole body w.w.
Calculation basis:
other: Log Pow and a regression derived equation.
Remarks on result:
other: WoE 2 and WoE 3
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be in the range 66 to 500 dimensionless, respectively. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain
Executive summary:

Data available of its read across chemicals has been reviewed to determine the bioaccumulation potential of test chemical. The studies are as mentioned below:

Bioaccumulation test was conducted for estimating the bioconcentration factor (BCF) of test chemical.The bioconcentration factor was determined to be 66 dimesionless, from an estimated log Pow of 3.28 and a regression derived equation.

Another bioaccumulation test was conducted for estimating the bioconcentration factor (BCF) of test chemical.The bioconcentration factor was determined to be 500 dimesionless, from an estimated log Pow of 8.69 and a regression derived equation.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be in the range 66 to 500 dimensionless, respectively. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be in the range 66 to 500 dimensionless, respectively. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain

Key value for chemical safety assessment

Additional information

Data available of its read across chemicals has been reviewed to determine the bioaccumulation potential of test chemical. The studies are as mentioned below:

Bioaccumulation test was conducted for estimating the bioconcentration factor (BCF) of test chemical.The bioconcentration factor was determined to be 66 dimesionless, from an estimated log Pow of 3.28 and a regression derived equation.

Another bioaccumulation test was conducted for estimating the bioconcentration factor (BCF) of test chemical.The bioconcentration factor was determined to be 500 dimesionless, from an estimated log Pow of 8.69 and a regression derived equation.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be in the range 66 to 500 dimensionless, respectively. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain