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Physical & Chemical properties

Vapour pressure

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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
04 November to 05 November 1998
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to EU test guidance in compliance with GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998
Report date:
1998

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: vapour pressure balance

Test material

Constituent 1
Details on test material:
Test substance; T-9601
Batch-No.: HI-295
Purity: 94.7% (w/w) ±0.5%
Certificate No., date: NB203 dated November 16, 1998
Physical state: Powder (visual observation)
Storage stability: 3 years in a refrigerator and dry. (information by the producer)
Expiration date of the certificate: May 2001

Results and discussion

Vapour pressure
Temp.:
25 °C
Vapour pressure:
0 hPa
Remarks on result:
other: Calculated by extrapolation from higher temperature results.

Any other information on results incl. tables

DSC Vapour Pressure results

Temperature [°C]

Vapour pressure [hPa]

80.6

1.0 x 10-5

85.0

2.6 x 10-5

85.6

1.6 x 10-5

89.1

5.7 x 10-5

93.9

8.9 x 10-5

99.6

1.3 x 10-4

104.4

1.9 x 10-4

113.1

4.0 x 10-4

114.6

5.2 x 10-4

120.8

6.7 x 10-4

125.3

9.1 x 10-4

126.0

8.7 x 10-4

129.7

9.9 x 10-4

136.8

1.1 x 10-3

137.5

1.1 x 10-3

142.1

1.2 x 10-3

148.4

1.4 x 10-3

150.3

1.5 x 10-3

152.0

1.7 x 10-3

 

Applicant's summary and conclusion

Conclusions:
The vapour pressure value for 25 °C is 1.10-7 hPa.
Executive summary:

The purpose of the test was the determination of the vapour pressure according to Guideline 92/69/EEC of 31 July 1992, Annex. Part A: Methods for the determination of physico-chemical properties. A.4.Vapour pressure. The study was conducted in compliance with the Principles of Good Laboratory Practice (GLP).

 

A Differential Scanning Calorimetry of the test substance was performed (see project SI074-98 - melting point). The measurement in a closed glass pan shows an endothermal effect (melting) and an exothermal effect beginning at 180 °C.

 

The vapour pressure was first measured at a temperature of 22.5 °C. At 80.6 °C the vapour pressure of the test substance was above the lower measuring limit.

 

The DSC measuring (SI074-98) shows the beginning of the melting process at about 130 °C, so the vapor pressure values at temperatures higher should be excluded. The first three values at the lower end of the recommended range are inconsistent, so this values should also be excluded. Therefore for calculating result the values in the temperature range 89.1 -129.7 °C are taken.

 

The vapour pressure value for 25 °C is 1.10-7 hPa.