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EC number: 248-433-6 | CAS number: 27375-52-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Species:
- other: Rattus norvegicus
- Strain:
- not specified
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 10 weeks
- Remarks:
- Doses / Concentrations:
5,10 and 25 mg/kg/day
Basis:
no data - No. of animals per sex per dose:
- 25 male/female
- Control animals:
- not specified
- Litter observations:
- Decreased litter size
- Dose descriptor:
- LOEL
- Generation:
- F2
- Effect level:
- 104.378 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Reproductive effects observed:
- not specified
- Conclusions:
- The two generation reproductive toxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus was observed at a dose concentration of 104.378 mg/kg bw/day.This indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus below the above mention dose.
- Executive summary:
The two generation reproductive toxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus was observed at a dose concentration of 104.378 mg/kg bw/day.This indicates thatN-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus below the above mention dose.
Reference
The prediction was based on dataset comprised from the following descriptors: LOEL
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= -1.2
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.0487
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- 104.378 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- K2 level data has been obtained from QSAR model considered by OECD.
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Toxicity to reproduction
The two generation reproductive toxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus was observed at a dose concentration of 104.378 mg/kg bw/day.This indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus below the above mention dose.
Short description of key information:
Study indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus.
Justification for selection of Effect on fertility via oral route:
The two generation reproductive toxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus was observed at a dose concentration of 104.378 mg/kg bw/day.This indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus below the above mention dose.
Effects on developmental toxicity
Description of key information
LOEL of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide was estimated to be 49.93153 mg/kg bw/day.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Species:
- other: Rattus norvegicus
- Strain:
- not specified
- Route of administration:
- oral: unspecified
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 10 days
- Remarks:
- Doses / Concentrations:
5,10 and 25 mg/kg/day
Basis:
no data - No. of animals per sex per dose:
- 25 female
- Control animals:
- not specified
- Dose descriptor:
- LOEL
- Effect level:
- 49.932 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: fetotoxicity
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
- Conclusions:
- The fetotoxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus by oral exposure was observed at a dose concentration of 49.93153 mg/kg bw/day . This indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus by the oral route below the above mention dose.
- Executive summary:
The fetotoxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus by oral exposure was observed at a dose concentration of 49.93153 mg/kg bw/day . This indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus by the oral route below the above mention dose.
Reference
The prediction was based on dataset comprised from the following descriptors: LOEL
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= -1.1
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.0486
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- 49.932 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- K2 level data has been obtained from QSAR model considered by OECD.
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Developmental toxicity / teratogenicity
The fetotoxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus by oral exposure was observed at a dose concentration of 49.93153 mg/kg bw/day . This indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus by the oral route below the above mention dose.Justification for selection of Effect on developmental toxicity: via oral route:
The fetotoxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus by oral exposure was observed at a dose concentration of 49.93153 mg/kg bw/day . This indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus by the oral route below the above mention dose.
Justification for classification or non-classification
According to the available information the substance is not classified in reprotoxic category.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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