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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
two-generation reproductive toxicity
Remarks:
based on test type (migrated information)
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
R: QSAR Toolbox 2.3.0.1132 prediction for LOEL read across evaluation for 27375-52-6
Author:
Sustainability Support Services (Europe) AB
Year:
2012
Bibliographic source:
QSAR Toolbox version 2.3

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Estimated data
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 2.3.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
EC Number:
248-433-6
EC Name:
N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
Cas Number:
27375-52-6
Molecular formula:
C10H13NO4S
IUPAC Name:
N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
Details on test material:
- Name of test material (as cited in study report): N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
other: Rattus norvegicus
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Type of inhalation exposure (if applicable):
not specified
Vehicle:
not specified
Duration of treatment / exposure:
10 weeks
Doses / concentrations
Remarks:
Doses / Concentrations:
5,10 and 25 mg/kg/day
Basis:
no data
No. of animals per sex per dose:
25 male/female
Control animals:
not specified

Examinations

Litter observations:
Decreased litter size

Results and discussion

Results: F2 generation

Effect levels (F2)

Dose descriptor:
LOEL
Generation:
F2
Effect level:
104.378 mg/kg bw/day
Based on:
test mat.
Sex:
male/female

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables






The prediction was based on dataset comprised from the following descriptors: LOEL
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

("a" and ("b" and "c" ) )

Domain logical expression index: "a"

Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is >= -1.2

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is <= 0.0487

Applicant's summary and conclusion

Conclusions:
The two generation reproductive toxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus was observed at a dose concentration of 104.378 mg/kg bw/day.This indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus below the above mention dose.
Executive summary:

The two generation reproductive toxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus was observed at a dose concentration of 104.378 mg/kg bw/day.This indicates thatN-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus below the above mention dose.