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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
Deviations:
not specified
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Reference substance name:
L-Cysteine, N-acetyl-
IUPAC Name:
L-Cysteine, N-acetyl-
Constituent 2
Reference substance name:
Acetylcysteine
EC Number:
210-498-3
EC Name:
Acetylcysteine
Cas Number:
616-91-1
IUPAC Name:
N-acetylcysteine
Test material form:
not specified

Results and discussion

Test results
Species / strain:
not specified
Metabolic activation:
not specified
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

The in vitro Ames Test with and without hepatic microsomes using as a test organism Salmonella typhimurium and at different N-Acteylcysteine concentrations evidenced no mutagenic effect.