Registration Dossier
Registration Dossier
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EC number: 200-158-2 | CAS number: 52-90-4
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Micronucleus Test in mice on 39 Food Additives and Eight Miscellaneous Chemicals
- Author:
- M. Hayashi, M. Kishi, T. Sofuni, M. Ishidate
- Year:
- 1 988
- Bibliographic source:
- Food and Chemical Toxicology, 26(6), 487-500
Materials and methods
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- L-Cysteine, hydrochloride
- IUPAC Name:
- L-Cysteine, hydrochloride
- Reference substance name:
- Cysteine hydrochloride
- EC Number:
- 200-157-7
- EC Name:
- Cysteine hydrochloride
- Cas Number:
- 52-89-1
- IUPAC Name:
- cysteine hydrochloride
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- Saline
- Frequency of treatment:
- 1 dose
- Post exposure period:
- 24h
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
125 mg/kg
Basis:
- Remarks:
- Doses / Concentrations:
250 mg/kg
Basis:
- Remarks:
- Doses / Concentrations:
500 mg/kg
Basis:
- No. of animals per sex per dose:
- 6
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- Mitomycin C
Results and discussion
- Additional information on results:
- No mortality
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Cystein Hydrochloride is negative in an in vivo micronucleus test in mice under the consditions described in the publication.
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