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Physical & Chemical properties

Partition coefficient

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In accordance with Annex XI section 2 of the Regulation EC 1907/2006, testing for a specific endpoint may be omitted, if it is technically not possible to conduct the study as a consequence of the properties of the substance. 
The following statement was included in a physico-chemical properties study by Walker & White (2010) concerning the feasibility of a partition coefficient study on the test substance:
"No determination was performed according to Method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008, for the following reasons:
• During preliminary investigations for the water solubility test, it was concluded that the test item hydrolysed fully within 30 minutes contact with water. Substances which hydrolyse rapidly in contact with water are not suitable for determination using Method A8.
• Estimation using the ratio of the solubility of the test item in n-octanol and water would also be unreliable due to the rapid hydrolysis of the test item in the water."

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