Registration Dossier

Toxicological information

Carcinogenicity

Currently viewing:

Administrative data

Description of key information

The following study has been submitted to address the carcinogenicity endpoint:
EFSA (2004) Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commision to assess the health risks to consumers associated with exposure to organotins in foodstuffs (Question No EFSA-Q-2003-110). The EFSA Journal 102: 1-119.
As the reference is secondary literature, it has been allocated a Klimisch score of 4.

Key value for chemical safety assessment

Justification for classification or non-classification

Additional information

According to theEFSA Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission to assess the health risks to consumers associated with exposure to organotins in foodstuffs (2004), no statistically significant increases in tumour incidences were observed inDibutyltin diacetatedosed rats or mice compared to the controls. An accidental loss of tissues from high dose female rats precluded an evaluation of the carcinogenicity of dibutyltin diacetate in female rats. However, the substance is not likely to be carcinogenic.