Registration Dossier
Registration Dossier
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EC number: 202-943-5 | CAS number: 101-43-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: "Appraisal of the safety of chemicals in foods, drugs and cosmetics"; Division of Pharmacology, FDA; according to the Draize Test, 1959
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexyl methacrylate
- EC Number:
- 202-943-5
- EC Name:
- Cyclohexyl methacrylate
- Cas Number:
- 101-43-9
- Molecular formula:
- C10H16O2
- IUPAC Name:
- cyclohexyl 2-methylprop-2-enoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean 2.5 kg
- Housing: single
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20
- Humidity (%): 45 - 55
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other flank of the same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h - 72h
- Score:
- 0.42
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h - 72h
- Score:
- 0.25
- Max. score:
- 4
- Reversibility:
- fully reversible
Any other information on results incl. tables
Raw data
|
No. of Animals |
24 h |
72 h |
Erythema |
1 |
0 |
0 |
|
2 |
0 |
0 |
|
3 |
2 |
1 |
|
4 |
1 |
0 |
|
5 |
1 |
0 |
|
6 |
0 |
0 |
Edema |
1 |
0 |
0 |
|
2 |
0 |
0 |
|
3 |
0 |
0 |
|
4 |
1 |
0 |
|
5 |
1 |
0 |
|
6 |
1 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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