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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: "Appraisal of the safety of chemicals in foods, drugs and cosmetics"; Division of Pharmacology, FDA; according to the Draize Test, 1959
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexyl methacrylate
EC Number:
202-943-5
EC Name:
Cyclohexyl methacrylate
Cas Number:
101-43-9
Molecular formula:
C10H16O2
IUPAC Name:
cyclohexyl 2-methylprop-2-enoate

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: mean 2.5 kg
- Housing: single
- Diet: ad libitum
- Water: ad libitum

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20
- Humidity (%): 45 - 55
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: other flank of the same animal
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
Duration of treatment / exposure:
24 hours
Observation period:
72 hours
Number of animals:
6
Details on study design:
TEST SITE
- Area of exposure: 2.5 x 2.5 cm

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24h - 72h
Score:
0.42
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24h - 72h
Score:
0.25
Max. score:
4
Reversibility:
fully reversible

Any other information on results incl. tables

Raw data

 

No. of Animals

24 h

72 h

Erythema

1

0

0

 

2

0

0

 

3

2

1

 

4

1

0

 

5

1

0

 

6

0

0

Edema

1

0

0

 

2

0

0

 

3

0

0

 

4

1

0

 

5

1

0

 

6

1

0

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met