3-chloro-p-toluidine

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Data source

Reference

Reference Type:

publication

Title:

3-Chloro-p-Toluidine: Effects of Lethal Doses in Rats and Cats

Author:

Borison HL, Snow SR, Longnecker DS, Smith RP

Year:

1975

Bibliographic source:

Toxicol Appl Pharmacol 31, 403-412 (1975)

Materials and methods

Principles of method if other than guideline:

Effects of lethal doses in rats and cats.

GLP compliance:

no

Applicant's summary and conclusion

Executive summary:

Chloro-p-toluidine (3-CPT) given systemically to rats or into the cerebroventricular system of cats produced death in respiratory arrest. Respiratory depression in cats can also be induced by the

rapid systemic infusion of 3-CPT, but methemoglobin formation and hemolysis are complications of the iv route in cats. The respiratory effects of 3-CPT in cats mimic those of surgical vagotomy, e.g., alterations in pattern, slowing of rate, and abolition of the Hering-Breuer reflex. Despite these drastic changes, the CO2-tidal volume response relationship was not altered.

Incidental effects observed after ip injection in rats, which may at least in part be secondary to hypoxia, include metabolic acidosis (lactic acidemia), hyperkalemia, hemoconcentration, loss of plasma proteins, and ascitic fluid in the abdomen. Rats also exhibited an early and transient skeletal muscle paralysis which is probably of central origin. A transient fall in blood pressure prior to the final state of collapse may be due to direct capillary vasodilation. In the late stages of collapse the peripheral vasodilation may be replaced by an increase in capillary permeability. 3-Chloro-ptoluidine appears to be directly cytotoxic, and on serosal surfaces it produced superficial necrosis l-6 cell layers deep after only 3-8 hr of contact.