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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Environmental fate & pathways


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Description of key information

Parent compound: In contact with water the substance will hydrolyse rapidly.
Hydrolysis product isobutyric acid: readily biodegradable.

Key value for chemical safety assessment

Additional information

Parent compound: Based on a weight-of-evidence approach, isobutyryl chloride is determined to hydrolyse rapidly to isobutyric acid and HCl. This is confirmed by read across to the analogue substances stearoyl chloride (CAS 112 -76 -5), 2 -ethylhexanoyl chloride (CAS 760 -67 -8), pivaloyl chloride (CAS 3282 -30 -2), neodecanoyl chloride (CAS 40292 -82 -8) and nonanyl chloride (CAS 764 -85 -2). All these compounds hydrolyse rapidly (<< 24 h) to the corresponding acid and HCl.

The measured data are supported by Hydrowin 2.00 data which indicate that acyl halides usually have hydrolytic half-lives of less than 10 minutes.


Hydrolysis product: In accordance with column 2 of REACH Annex VII, the study does not need to be performed if the substance is readily biodegradable or inorganic. Isobutyryl chloride hydrolyses rapidly and forms isobutyric acid and HCl. Isobutyric acid is readily biodegradable (Henkel KGaA 1983), while HCl is inorganic.