3,4-dichlorobut-1-ene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP-Guideline study. Adopted according to OECD SIDS (public available peer reviewed source). The original source is not available and has not been reviewed.

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

SIDS Initial Assessment Report for 11th SIAM

Author:

OECD SIDS

Year:

2003

Bibliographic source:

UNEP Publications

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1993

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

3,4-dichlorobut-1-ene

EC Number:

212-079-0

EC Name:

3,4-dichlorobut-1-ene

Cas Number:

760-23-6

Molecular formula:

C4H6Cl2

IUPAC Name:

3,4-dichlorobut-1-ene

Details on test material:

- Name of test material (as cited in study report): 3,4-dichlorobut-1-ene
- Analytical purity: Sample 1: 99.67 wt %; Sample 2: 98.26 wt %.

Test animals

Species:

rabbit

Sex:

male/female

Details on test animals or test system and environmental conditions:

no further data

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Details on dermal exposure:

no further data

Duration of exposure:

24 hours

Doses:

Intact skin of groups of 5 male and 5 female rabbits each at dosages of 700 or 2000 mg/kg. Additionally, 1 female rabbit was treated at 1000 mg/kg.

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days (except the additional group dosed at 2000 mg/kg. The additional group dose at 2000 mg/kg was sacrificed 2 days after application of the test substance and animals were not necropsied)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Statistics:

No data

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths occurred during the study.

Clinical signs:

other: After treatment for 24 hours slight to severe erythema and no to mild edema were observed. Dermal erythema persisted in most rabbits throughout the observation period. Most rabbits exhibited epidermal scaling and sloughing from day 5 to 6 throughout the r

Gross pathology:

No further data

Other findings:

Most rabbits from all dose groups were hypo-responsive to auditory (finger snap and hand clap) and tactile (face touching) stimuli up to approx. 4 hours after dosing.