Registration Dossier
Registration Dossier
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EC number: 212-079-0 | CAS number: 760-23-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study. Adopted according to OECD SIDS (public available peer reviewed source). The original source is not available and has not been reviewed.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report for 11th SIAM
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- UNEP Publications
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3,4-dichlorobut-1-ene
- EC Number:
- 212-079-0
- EC Name:
- 3,4-dichlorobut-1-ene
- Cas Number:
- 760-23-6
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 3,4-dichlorobut-1-ene
- Details on test material:
- - Name of test material (as cited in study report): 3,4-dichlorobut-1-ene
- Analytical purity: Sample 1: 99.67 wt %; Sample 2: 98.26 wt %.
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no further data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- no further data
- Duration of exposure:
- 24 hours
- Doses:
- Intact skin of groups of 5 male and 5 female rabbits each at dosages of 700 or 2000 mg/kg. Additionally, 1 female rabbit was treated at 1000 mg/kg.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (except the additional group dosed at 2000 mg/kg. The additional group dose at 2000 mg/kg was sacrificed 2 days after application of the test substance and animals were not necropsied)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred during the study.
- Clinical signs:
- other: After treatment for 24 hours slight to severe erythema and no to mild edema were observed. Dermal erythema persisted in most rabbits throughout the observation period. Most rabbits exhibited epidermal scaling and sloughing from day 5 to 6 throughout the r
- Gross pathology:
- No further data
- Other findings:
- Most rabbits from all dose groups were hypo-responsive to auditory (finger snap and hand clap) and tactile (face touching) stimuli up to approx. 4 hours after dosing.
Applicant's summary and conclusion
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